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Dedifferentiated liposarcoma
3 associated genes
No signs/symptoms info
PROTEIN INTERACTIONS: 1
Meacham syndrome
1 OMIM reference -
1 associated gene
22 signs/symptoms
Dedifferentiated liposarcoma
Meacham syndrome

CDK4
(UniProt - OMIM)
 WT1
(UniProt - OMIM)
HMGA2
(UniProt - OMIM)
MDM2
(UniProt - OMIM)

INTERACTOME
ASSOCIATIONS
(click on a score value to see the evidence)
MDM2
(0.63)
WT1


Citations in the biomedical literature:


Dedifferentiated liposarcoma
CDK4 HMGA2 MDM2
Meacham syndrome
WT1



Dedifferentiated liposarcoma
Meacham syndrome

Synonym(s):
- DDLS
Synonym(s):
- Meacham-Winn-Culler syndrome
- Rhabdomyomatous dysplasia - cardiopathy - genital anomalies
Classification (Orphanet):
- Rare oncologic disease
Classification (Orphanet):
- Rare developmental defect during embryogenesis
- Rare endocrine disease
- Rare genetic disease
- Rare gynecologic or obstetric disease
- Rare urogenital disease
Classification (ICD10):
- Neoplasms -
Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -
Epidemiological data:
Class of prevalence: unknown
Average age onset: adulthood
Average age of death: adult
Type of inheritance: sporadic
Epidemiological data:
(no data available)
External references:
No OMIM references
No MeSH references
External references:
1 OMIM reference -
No MeSH references
Meacham syndrome

Very frequent
- Ambiguous genitalia
- Diaphragmatic hernia / defect / agenesis
- Hypoplastic lungs / pulmonary hypoplasia / agenesis
- Uterine / uterus / Fallopian tubes anomalies
- Vagina anomalies / atresia / hydrometrocolpos / hymen imperforation

Frequent
- Absent lobe / lung / segmentation defect / abnormal lobulation / sequestration
- Death in infancy
- Hypoplastic left heart / ventricle
- Micropenis / small penis / agenesis
- Stillbirth / neonatal death
- Structural and functional anomalies of the spleen
- Undescended / ectopic testes / cryptorchidia / unfixed testes

Occasional
- Anomalous pulmonary venous return
- Asplenia / polysplenia / spleen lobulation / accessory spleen
- Atrial septal defect / interauricular communication
- Dextrocardia / abnormal heart position / cardiac heterotaxia / situs inversus
- Ectopic / horseshoe / fused kidneys
- Hypoplastic aorta / coarctation / stenosis / anomaly / aortic arch interruption
- Patent ductus arteriosus
- Tetralogy of Fallot / trilogy of Fallot
- Transposition of great vessels
- Ventricular septal defect / interventricular communication


Dedifferentiated liposarcoma

(no data available)